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Today’s show: Alex is back with three more awesome interviews with founders on the bleeding edge of innovative tech. - Dr. Hon Weng Chong walks us through the basics of biological computing and Cortical Labs’ first-ever commercial computer running on living human cells.
- Turing founder Jonathan Siddarth unpacks the secrets of LLM benchmarking, and explains why even our most advanced tests need to get much much harder right away.
- Finally, Mercor founder Brendan Foody on how AI is about to reinvent the hiring process, and marrying the effectiveness of recruiters with the ease of online job boards.
It’s three — count ’em, three — can’t miss TWiST interviews guaranteed to make you smarter Timestamps: (0:00) OpenAI’s GPT-5: When is it coming out? Is it going to be TOO smart? (08:06) Cortical Labs’ Hon Weng Chong on the electric connection between neuroscience and machine learning (10:20) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today! (11:27) Show Continues… (15:17) The extreme difficulty of going from the lab to a shippable product (20:00) .TECH: Say it without saying it. Head to www.get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today. (21:05) Show Continues… (28:15) Why data is a factor of time (29:52) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit aws.amazon.com/startups/credits (31:16) Show Continues… (42:44) Turing CEO Jonathan Siddarth explains why it’s so important to keep benchmarking our LLMs (47:24) What it means when a model “saturates” a test, and why benchmarks need to get HARDER (50:22) What happens with the LLMs can answer all of our smartest questions? (53:44) AI Agents train in gyms? Wait, really? (01:01:33) Coding teaches models how to think, and more training mysteries don’t understand (01:03:11) Brendan Foody from Mercor explains the “matching problem” that makes hiring such a pain (01:07:02) How Mercor combines a job board’s distribution with the value of a recruitment agency (01:10:49) Brendan recalls building his first AI interviewer in his college dorm (01:20:16) Mercor has the opposite of a retention problem and crazy growth Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: (10:20) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today! (20:00) .TECH: Say it without saying it. Head to www.get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today. (29:52) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit aws.amazon.com/startups/credits Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Check out Jason’s suite of newsletters: https://substack.com/@calacanis Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com Subscribe to the Founder University Podcast: https://www.youtube.com/@founderuniversity1916 |
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