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Home > This Week in Parasitism > TWiP 180: A spleen palaver
Podcast: This Week in Parasitism
Episode:

TWiP 180: A spleen palaver
Category: Science & Medicine
Duration: 01:21:57
Publish Date: 2020-02-08 12:02:33
Description:

The TWiP professors solve the case of the Ugandan Child with Splenomegaly, and reveal that mutations in the P. falciparum genome that confer artemisinin resistance interfere with endocytic uptake of hemoglobin.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

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Case Study for TWiP 180

Uganda with a twist. Meets two people with watery diarrhea, 12 episodes/day, loss of appetite. No fever, no blood in stool. Living for months at staff guest house. One week prior to onset went on weekend trip to area with waterfalls. Were served outdoor meal: meat, salad, fruit. Recommends empiric treatment trimethoprim/sulfamethoxzole for 7 days. Prompt resolution of diarrhea. A few days later, upon drinking coffee with milk gets severe cramps. 20s, long term female volunteers. 

Send your case diagnosis, questions and comments to twip@microbe.tv

Music by Ronald Jenkees
Total Play: 0

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