Guests:
Dr. Jacqueline Barry is the Chief Clinical Officer at Cell and Gene Therapy Catapult, Dr. Kapil Bharti is a Senior Investigator at the National Eye Institute at the National Institutes of Health, and Dr. Jack Mosher is the Scientific Director at the International Society for Stem Cell Research (ISSCR). They discuss their work on the ISSCR’s Best Practices for the Development of Pluripotent Stem Cell-Derived Cellular Therapies. They talk about the need for consistency and rigor in cell therapy development, and how the document can be navigated and applied across jurisdictions.
Featured Products and Resources:
The Stem Cell Science Round Up
Gene Editing for a Rare Genetic Disease – A customized lipid nanoparticle-delivered base-editing therapy was used to treat a neonate with severe carbamoyl-phosphate synthetase 1 deficiency.
Digitalized Organoids – An AI-powered pipeline allows for plug-and-play image analysis of diverse 3D cellular structures across multiple imaging resolutions.
Post-Gastrulation Amnioids – Amnioids mimic the cellular identities, proteome, and metabolome of the human amniotic sac.
Cerebral Cortex Expansion – A human accelerated region enhancer modulates cortical development by influencing neural progenitor cell behavior.
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