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Home > The Stem Cell Podcast > Ep. 291: “Functional Precision Medicine” Featuring Dr. Scott Younger

Podcast:

The Stem Cell Podcast

Episode:

Ep. 291: “Functional Precision Medicine” Featuring Dr. Scott Younger

Category:

Science & Medicine

Duration:

01:25:08

Publish Date:

2025-04-01 19:00:08

Description:

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Guest:

Dr. Scott Younger is the Director of Disease Gene Engineering within the Genomic Medicine Center at Children’s Mercy Hospital. His research focuses on producing patient-derived cellular models to develop functional precision medicine. He talks about using personalized antisense oligonucleotides to reverse disease phenotypes in organoid models of Duchenne muscular dystrophy. He also discusses his lab’s personal connections to the rare disease community and the opportunities for collaborations with clinicians at Children’s Mercy. (36:52)

The Stem Cell Science Round Up

Chronic Stress and Intestinal Stem Cells – Chronic impairs the stemness of intestinal stem cells via the vagal pathway. (1:43)

Liver Regeneration – Glutamate metabolically reprograms bone marrow-derived macrophages, subsequently boosting liver regeneration. (9:40)

CRISPR Activation in Embryo Models – CRISPR activation-programmed embryo models mimic the pre-gastrulation embryonic stage. (18:30)

Retinal Regeneration – Human neural retinal stem-like cells in fetal retinas exhibit substantial self-renewal and differentiation potential. (27:45)

Image courtesy of Dr. Scott Younger