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Home > The Knowledge and Mileage Podcast > 226. Why NAD3 Crushes NMN & NR (The Truth About Cellular Energy)
Podcast: The Knowledge and Mileage Podcast
Episode:

226. Why NAD3 Crushes NMN & NR (The Truth About Cellular Energy)
Category: Health
Duration: 00:18:06
Publish Date: 2025-09-25 08:00:00
Description:

Most NAD+ supplements are fluff. NMN? NR? They’re precursors, half the story. In this episode, I break down why NAD3 isn’t just another molecule, it’s the master key for energy, recovery, and longevity.

We get into the real science: how NAD+ fuels your mitochondria, repairs DNA, activates sirtuins, and slows aging at the cellular level. I explain why levels crash after 40, how stress, toxins, and training hammer your reserves, and why NMN/NR often fail thanks to CD38 and PARP overactivity.

You’ll learn why NAD3 bypasses the weak links, how it stacks with spermidine, glutathione, and autophagy activators, and why Regen NAD is the one I actually use daily, because it works.

Forget the hype. This is metabolic firepower that hits. If you’re overtrained, under-recovered, or want to stay biologically younger for longer: listen in.

What's Discussed:

[00:30] – What Is NAD+ and Why It’s Non-Negotiable [03:30] – Why Your NAD Levels Plummet After 40 [07:15] – NMN & NR: Overhyped Precursors That Don’t Deliver [09:30] – NAD3: The Smarter, More Effective Upgrade [11:00] – My Daily NAD Protocol (and Why IVs Suck)

 

Thank You for Our Sponsors:

My Go-To for Gut Health: Glutamine and Imuno-IGG from Unmatched Supplements: https://www.unmatchedsupps.com/collections/digestion-gut-health

Find more from Kris:

Website: https://www.krisgethin.com/ Website:https://www.unmatchedsupps.com

Instagram: @krisgethin 

Youtube: https://www.youtube.com/krisgethin 2 Shred: https://www.unmatchedsupps.com/products/2shred 
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