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Home > My Kid Cures Cancer > Circulating Tumor Cells | Dr. Dan Rubin | Ryan Sternagel
Podcast: My Kid Cures Cancer
Episode:

Circulating Tumor Cells | Dr. Dan Rubin | Ryan Sternagel
Category: Health
Duration: 00:57:01
Publish Date: 2021-01-21 15:08:27
Description:

show notes @ https://thesternmethod.com/circulatingtumorcells/

KEY TAKEAWAYS

1.

What are CTCs and what do they mean?

  • Cells from a collection of cancer cells, tumor or metastatic deposit
  • Sometime seen on scans but not always
  • Circulate in the blood or lymphatic tissues
  • Can only test for the CTC in blood. Need biopsy to detect in lymphatic tissue
  • The presence of CTCs doesn’t necessarily indicate metastatic cancer
  • CTCs don’t live very long in the blood – persistent CTC is cause for concern

    Cancer spreads in two ways

  • Metastasize (means “evil spread”) - cells travel via blood vessels
  • Direct invasion - cells invade the tissues and then access lymphatic system or blood stream

    What to look for in CTC testing

  • Only available for certain cancers – ovarian, pancreatic, colon, lung, breast, prostate
  • Looking for two different populations of CTCs- cytokeratin(CK)-positive and CK-negative
    • ➔  CK is an anchor molecule for cells
    • ➔  CK-negative cells are cells that have down regulated their CK and can leave the

      tissue space to ‘circulate’ as a CTC

    • ➔  CK-positive cells are rarely found in CTC tests unless through trauma or if the tumor is invasive
    • ➔  CK-negative cells can revert back to CK-positive and “anchor in” to a new tissue site
  • Test results provide highly individual information about that person’s specific tumor
  • Can also see some markers you’d see on pathology specimens - things that sit on the surface of cells such as androgen and estrogen receptors

    Hosted By:

2.

3.

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  1. When to test for CTCs
    • At diagnosis and before treatment, when cancer is the highest
    • During treatment to gauge therapeutic response
    • Post treatment testing to determine if cancer is still present or to identify recurrences
  2. What to do with CTC test results
    • Depends on the patient – their history, the cancer, how aggressive, treatment proto- cols undertaken. Every situation/person is different
    • Run other lab tests to look at supporting factors in the blood and fix those: ➔ Inflammatory markers ➔ Cell markers ➔ Immune markers

      ➔ Tissue markers

      ➔ Hormones

      ➔ Tissues at risk – liver, lung, bones

      ➔ Nutrient levels

      ➔ Vitamin D – 25-Hydroxy and 1,25-Dihydroxy

      ➔ Look at lifestyle – diet, toxins, air, water

    • Goal is to shut down the flow of CTC into the blood

      CASE STUDIES / CLINICAL EXAMPLES / DIAGNOSES REFERENCED

      Breast cancer Colon cancer Lung cancer Ovarian cancer Pancreatic cancer Prostate cancer

      STUDIES / ARTICLES / CLINICAL TRIALS REFERENCED

N/A

BOOKS REFERENCED

N/A

Hosted By:

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SUPPLEMENTS REFERENCED

N/A

THERAPIES REFERENCED

IV Vitamin C IV Quercetin Mistletoe therapy

OTHER RESOURCES

Biocept

FOLLOW DR RUBIN

Listenandcare.com Aspenmedcenter.com PH: 480.990.1111 Remote consultations available
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