Search

Home > Emergency Medical Minute > Podcast 797: Vitamin C in Sepsis
Podcast: Emergency Medical Minute
Episode:

Podcast 797: Vitamin C in Sepsis
Category: Science & Medicine
Duration: 00:02:43
Publish Date: 2022-07-12 10:00:40
Description:

Contributor: Aaron Lessen, MD

Educational Pearls:

  • Prior, smaller studies showed intravenous Vitamin C given to patients with sepsis significantly improved patient mortality and additional outcomes. 
  • A recently published, randomized control trial with >800 ICU patients who received up to 4 days of IV Vit C or placebo concluded that the end points of death or persistent organ dysfunction at 28 days were unaffected by Vitamin C administration. There were no adverse safety outcomes associated with Vitamin C administration.  
  • Based on this trial, it is unlikely that Vitamin C will become a mainstay of treatment for sepsis patients. 

 

References

Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2017;151(6):1229-1238. doi:10.1016/j.chest.2016.11.036

Lamontagne F, Masse MH, Menard J, et al. Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit. N Engl J Med. 2022;386(25):2387-2398. doi:10.1056/NEJMoa2200644

 

Summarized by Kirsten Hughes, MS4 | Edited by John Spartz, MD & Erik Verzemnieks, MD

 

The Emergency Medical Minute is excited to announce that we are now offering AMA PRA Category 1 credits™ via online course modules. To access these and for more information, visit our website at https://emergencymedicalminute.org/cme-courses/ and create an account. 

Donate to EMM today!
Total Play: 0

Users also like

800+ Episodes
Radioresepsj .. 700+     10+
20+ Episodes
Lung Story S .. 70+     10+