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Home > Emergency Medical Minute > Podcast 551:  PPIs are Not Benign
Podcast: Emergency Medical Minute
Episode:

Podcast 551:  PPIs are Not Benign
Category: Science & Medicine
Duration: 00:03:26
Publish Date: 2020-03-23 11:16:41
Description:

 

Contributor: Don Stader, MD

Educational Pearls:

  • PPIs (Proton pump inhibitors) reduce stomach acid levels and are commonly prescribed in patients with GERD or peptic ulcer disease
  • Stopping a PPI after sustained use for a month or longer can lead to withdrawal - causing a rebound indigestion or reflux due to a surge in acid production
  • Long term PPI use has noteworthy side effects including increased incidence of bacterial GI infections and pneumonia
  • Be cautious in prescribing a PPI for over 2 weeks. If continued indigestion control is needed, transition to a H2 blocker or OTC antacids if prolonged treatment is needed.

References

1)Haastrup PF, Thompson W, Søndergaard J, Jarbøl DE (2018) Side effects of long-term proton pump inhibitor use: a review. Basic Clin Pharmacol Toxicol 123(2):114–121. https://doi.org/10.1111/bcpt.13023 Review

2) Helgadottir, H.; Bjornsson, E.S. Problems Associated with Deprescribing of Proton Pump Inhibitors. Int. J. Mol. Sci. 2019, 20, 5469.

 

Summarized by Jackson Roos, MS3 | Edited by Erik Verzemnieks, MD
Total Play: 0

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