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Does anything work to reverse angioedema? If it's hereditary,
then icatibant may do the trick. Otherwise, there's not much out
there. Fresh frozen plasma (FFP) has it's place in angioedema lore
as something that works, but the evidence in its favor is a series
of case reports. Emergency physician and angioedema researcher
Gentry Wilkerson gives a State of the Union on the known knowns and
known unknowns of this sometimes mysterious disease.
Links mentioned in this show
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Essentials of Emergency Medicine
Angioedema algorithms
Cicardi, Marco, et al. "Guidance for diagnosis and treatment of
acute angioedema in the emergency department: consensus statement
by a panel of Italian experts." Internal and emergency
medicine 9.1 (2014): 85-92. Link
Bowen, Tom, et al. "2010 International consensus algorithm for
the diagnosis, therapy and management of hereditary
angioedema." Allergy, Asthma & Clinical
Immunology 6.1 (2010): 1-13. Link
Chiu, Alexander G., et al. "Angiotensin-converting enzyme
inhibitor-induced angioedema: a multicenter review and an algorithm
for airway management." Annals of Otology, Rhinology &
Laryngology 110.9 (2001): 834-840. Link
Hassen, Getaw Worku, et al.
"Fresh frozen plasma for progressive and refractory
angiotensin-converting enzyme inhibitor-induced
angioedema." The Journal of emergency
medicine 44.4 (2013):
764-772. Link |