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Home > ERCAST > 45. The Story Behind COVID Vaccines and Brain Blood Clots
Podcast: ERCAST
Episode:

45. The Story Behind COVID Vaccines and Brain Blood Clots
Category: Religion & Spirituality
Duration: 00:28:20
Publish Date: 2021-04-16 00:16:55
Description:

The news this week has been replete with stories about increased clot risk in those who have received the AstraZeneca and Johnson & Johnson COVID-19 vaccines. In this episode, we break down: what we know so far about vaccine induced thrombotic thrombocytopenia (VITT), the research that has revealed an underlying mechanism, CDC and NHS recommendations, and a primer on cerebral venous thrombosis -- the primary clot site associated with VITT.

We Discuss:

Vaccine induced thrombotic thrombocytopenia (VITT)

  • The similar mechanism of AstraZeneca's and Johnson & Johnson's COVID-19 vaccines [01:00];
  • Proposed mechanism of VITT [03:20];
  • Types of clots associated with VITT [04:00];
  • Incidence of VITT in the US and UK [05:00];
  • The CDC and NHS rallying cry to treat this differently that other causes of cerebral venous thrombosis (CVT) [06:30];
  • The UK algorithm for evaluating and managing patients with suspected VITT [08:00];

A primer on CVT

  • Why CVT can cause problems [10:30]
  • Presenting symptoms of CVT [11:00]
  • Physical exam findings and the sensitivity of papilledema [15:00]
  • Using D-dimer in the evaluation of CVT [16:50];
  • A new clinical score for CVT [19:00];
  • Utility of spinal tap as a rule out test [21:00];
  • Imaging options (CT venogram vs MR venogram) [22:00];
  • CDC treatment recommendations for  VITT associated CVT and how it’s different than most other CVT’s [25:00];
  • Testing patients with VITT for heparin-PF4 antibodies and how that may guide whether or not to use IVIG [26:35].

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