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Home > Active Motif's Podcast > Identification of Functional Elements in the Genome (Bing Ren)
Podcast: Active Motif's Podcast
Episode:

Identification of Functional Elements in the Genome (Bing Ren)
Category: Science & Medicine
Duration: 00:43:02
Publish Date: 2020-05-07 08:08:29
Description:

In this episode of the Epigenetics Podcast, we caught up with Bing Ren, Ph.D., from the University of California, San Diego and the Ludwig Institute for Cancer Research to talk about his work on identifying functional elements of the genome and higher order genome structure.

 

Dr. Ren’s lab invented an approach for finding cis-elements that involves the identification of transcription factor binding sites and chromatin modification status genome-wide using chromatin immunoprecipitation-based methods. His group demonstrated that this is an effective approach for genome-wide mapping of cis-elements, and their approach has now been widely adopted in the field. Among many other distinctions, Bing Ren's group was also a major contributor to the ENCODE Project.

 

His lab recently discovered that the mammalian genomes are partitioned into a few thousand megabase-sized domains, which display strong local chromatin interactions but infrequent inter-domain interactions. These domains are surprisingly stable during development and are evolutionarily conserved. The physical partitioning of the genome provides a structural basis for understanding long-range regulatory functions by distal enhancers, which are often located hundreds of kilobases away from their target genes.

  

In this interview, we discuss the road of Bing Ren's scientific career, his role in the ENCODE Project and Roadmap Epigenome Consortia, and the discovery of Topologically associating domains (TADs).

 

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