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This week: Cryptogenic Stroke and Atrial Fibrillation, Naloxegol for Opioid-Induced Constipation
Fahad and Amol want you to:
1. Appreciate the importance of subclinical atrial fibrillation in cryptogenic stroke and consider longer monitoring to detect it.
2. Recognize Naloxegol as a targeted therapy for opioid-induced constipation that is more effective than placebo but its effectiveness has not been compared directly with existing laxative therapies.
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The papers
David Gladstone et al. Atrial Fibrillation in Patients with Cryptogenic Stroke. NEJM. 2014; 370:2467-2477.
William Chey et al. Naloxegol for Opioid-Induced Constipation in Patients with Noncancer Pain. NEJM. 2014;370:2387-2396.
Other articles mentioned
Tommaso Sanna et al. Cryptogenic stroke and underlying atrial fibrillation. NEJM. 2014;370(26):2478–2486. doi:10.1056/NEJMoa1313600.
Good stuff
Fahad:
http://www.nytimes.com/2014/06/22/us/dr-arnold-relman-outspoken-medical-editor-dies-at-91.html
http://www.nytimes.com/2012/03/20/science/a-drumbeat-on-profit-takers.html
Relman AS. The new medical-industrial complex. New England Journal of Medicine. 1980;303(17):963–970. doi:10.1056/NEJM198010233031703.
Amol:
The Longitude Prize 2014
The post Getting “Travis-y”: Stroke and AFib, Naloxegol for Opioid Constipation appeared first on Healthy Debate. |