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Chemical probes are reshaping how we map GLP-1R in real time — revealing receptor pools antibodies can’t reliably capture.
This is Episode 2 of a 3-part GPCR tool-development series created in partnership with Celtarys Research.
Summary:
Dr. Johannes Broichhagen aka JB breaks down the design logic behind fluorophore-linked peptides, assay trade-offs, and what true receptor internalization looks like in live tissue. A concise masterclass in assay development and GPCR drug discovery.
What you’ll learn:
• Why antibody variability pushed JB toward chemical probe engineering • The design logic behind Luxendin-based fluorescent tools — and how structure guides function • What “good assay development” looks like when cells, tissue, and probe behavior collide • Behind-the-scenes stories from the collaboration with David Hodson • Why parallelized experiments matter for reproducibility and signal quality • How small-molecule probes outperform antibodies in live-cell and tissue imaging • The surprising breakthroughs that shifted JB’s entire research trajectory • Future directions: multi-color GPCR mapping, AI-guided ligand design, and in vivo chemical biology
Dr GPCR Links & Resources: • Dr. GPCR Ecosystem: https://www.ecosystem.drgpcr.com/
• Membership & Pricing: https://www.ecosystem.drgpcr.com/university-pricing• Weekly News: https://www.ecosystem.drgpcr.com/gpcr-weekly-news |
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