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Home > Learning With Lowell > targeting the mechanisms of treatment resistance in cancer with Nicholas  Goldner | 222
Podcast: Learning With Lowell
Episode:

targeting the mechanisms of treatment resistance in cancer with Nicholas  Goldner | 222
Category: Science & Medicine
Duration: 01:18:04
Publish Date: 2023-09-26 15:00:00
Description: Nicholas Goldner, PhD, is the CEO and co-founder of resistanceBio, where he leads a mission to outsmart cancer by developing innovative therapies targeting treatment resistance mechanisms. He also serves as a venture partner at Pioneer Fund, actively investing in and supporting early-stage founders solving complex problems with science and technology. With a distinguished academic background, including a PhD in Molecular Cell Biology from Washington University in St. Louis, Nicholas combines scientific expertise with entrepreneurial prowess to create impactful solutions for pressing health challenges. Newsletter sign up (new and exciting developments) https://learningwithlowell.us12.list-manage.com/subscribe?u=08ed8a56013d8b3a3c01e27fc&id=6ecaa9189b Join this channel to get access to perks: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q/join Over 321 books from 170 plus interviews over 5 years https://www.learningwithlowell.com/over-321-books-from-170-interviews-over-5-years-for-autodidacts/ https://youtu.be/h-xQBKlgAoQ PODCAST INFO: The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKS Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH RSS: https://www.learningwithlowell.com/feed/podcast/ Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA Website: https://www.learningwithlowell.com/ Nicholas Goldner links https://www.linkedin.com/in/nicholas-goldner/ https://www.resistance.bio/ Timestamps 00:00 Introducing Nicholas Goldner and ResistanceBIO 00:30 Saving 600,000 people a year 01:30 ENCER models for pharma  04:30 Importance of ResistanceBIO to understanding cancer 05:40 Why cancer comes back / resistance mechanisms 07:30 Cure vs treatment  09:00 Cancer is natural   10:30 Full ResistanceBIO platform explained  14:55 Last 3 years of development  17:30 Knowing they were on the right path, supportive data,  and deeper understanding 24:50 Business incentive and business model explained  28:30 Hiding cure for cancer myth 31:00 Diagnostic potential 32:30 Last things pharma is looking for from them 34:30 Confidence in targeting/ therapy 35:45 Platform helping understand why failures happen 38:00 Adding 10,000,000,000 years of life 40:20 Nerding out and coffee  41:20 Headache caffeine  41:55 Looking to hire - cell culture scientist work 43:55 Key experiences that will translate into the role 45:55 Cellular agriculture / specialization 48:10 How do ENCER models differ from CRISPR, Organoids, and Animal models in terms of simulating resistance (FanQ) 54:30 What is left to do / what he needs help with 58:45 Immunotherapy and landscape change for cancer treatment and cure 01:01:40 Next 5 years and Lowell offers to chase Nick 01:03:50 Handling burnout and mental health  01:07:40 Art / being creative / painting 01:12:05 What books is he reading and what he recommends 01:14:23 Foundation apple tv show 01:15:10 Retirement for Nick 01:16:55 Police brutality episode https://www.youtube.com/watch?v=WgKBIb6Zb5c 01:17:40 Non resistance life
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