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Home > Gastroenterologie > Inhibition of PDGFRβ in colorectal cancer cells leads todecreased proliferation and G2 cell cycle arrest
Podcast: Gastroenterologie
Episode:

Inhibition of PDGFRβ in colorectal cancer cells leads todecreased proliferation and G2 cell cycle arrest
Category: Science & Medicine
Duration:
Publish Date: 2012-06-18 10:21:05
Description: Colorectal cancer (CRC) is the second leading cause of cancer‐related deaths in the western world and growth factors and their receptors play a significant role in the regulation of CRC growth, angiogenesis, and metastasis. The platelet‐derived growth factor receptor (PDGFR) has attracted increasing attention as potential target of anti‐tumor therapy in CRC. In the current work, we analyzed the effect of blocking the PDGFRβ on cellular functions such as proliferation, viability and cell cycle regulation in the CRC cell line SW480.
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