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	Podcast:		the bioinformatics chat
	Episode:		#6 Allele-specific expression
	Category:		Science & Medicine
	Duration:		00:33:29
	Publish Date:		2017-06-25 14:00:00
	Description:		I talk about allele-specific expression: why it arises and how it can be reliably detected. Sections: The biology of allele-specific expression (2:17) Detecting allele-specific expression with RNA-seq (7:46) Mapping and sequencing biases (16:39) The experiment in yeast (19:47) Statistical models (21:44) Links: A powerful and flexible statistical framework for testing hypotheses of allele-specific gene expression from RNA-seq data Supplemenal information Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data The talk by John Marioni The blog post explaining the RSEM model
	Total Play:		0