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Home > the bioinformatics chat > #56 Polygenic risk scores in admixed populations with Bárbara Bitarello
Podcast: the bioinformatics chat
Episode:

#56 Polygenic risk scores in admixed populations with Bárbara Bitarello
Category: Science & Medicine
Duration: 01:30:12
Publish Date: 2021-02-17 19:00:00
Description:

Polygenic risk scores (PRS) rely on the genome-wide association studies (GWAS) to predict the phenotype based on the genotype. However, the prediction accuracy suffers when GWAS from one population are used to calculate PRS within a different population, which is a problem because the majority of the GWAS are done on cohorts of European ancestry.

In this episode, Bárbara Bitarello helps us understand how PRS work and why they don’t transfer well across populations.

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