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Podcast: A Grey Matter
Episode:

Rethinking schizophrenia treatment
Category: Science & Medicine
Duration: 00:30:39
Publish Date: 2026-05-20 06:00:00
Description:

Antipsychotic drugs, like clozapine, can  stabilise some schizophrenia symptoms, but they do not cure the illness and can cause severe side effects.

At UQ, a neuroscientist, a chemist and a psychiatrist have hit on a formulation that may revolutionise the treatment of schizophrenia. The research team, led by Professor Darryl Eyles and Dr Xiaoying Cui, are investigating a new delivery mode for clozapine, in the hope that it may be better tolerated by patients and improve their quality of life.

In this engaging conversation, Darryl and Xiaoying discuss: 

  • Treatment-resistant schizophrenia and the side-effects of clozapine
  • Collaborating with chemists to develop intranasal delivery
  • What they have found so far in preclinical studies 
  • The potential impact of their research on schizophrenia treatment

Related resources

Epitranscriptomic regulation of striatal function: a new neurobiology of schizophrenia

Schizophrenia research at QBI 
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