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Home > HEPATOLOGY Podcast > A New Non-invasive Test for NASH
Podcast: HEPATOLOGY Podcast
Episode:

A New Non-invasive Test for NASH
Category: Science & Medicine
Duration: 00:14:32
Publish Date: 2013-01-28 17:11:50
Description: Drs. Stephen Harrison and Sudeep Tanwar Liver biopsy is the reference standard for the detection of nonalcoholic steatohepatitis (NASH) within nonalcoholic fatty liver disease (NAFLD). The aim of this study was to identify a biomarker of NASH in patients without significant fibrosis. In all, 172 patients from two centers with biopsy-proven NAFLD were included in this study. Eighty-four patients from a single center were included as a derivation cohort and 88 patients from a second center were included as a validation cohort. Serum samples were tested for candidate markers of fibrosis and inflammation alongside hematological and biochemical markers. Among patients without advanced fibrosis, terminal peptide of procollagen III (PIIINP) was the only marker found to be associated with a histological diagnosis of NASH in both cohorts. PIIINP also correlated with the total NAFLD activity score (NAS) and its constituent components (P
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