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Home > Diabetes Knowledge into Practice Podcast > What are the cardiorenal effects of combining SGLT2is with GLP-1 RAs? | With Dr Darren McGuire
Podcast: Diabetes Knowledge into Practice Podcast
Episode:

What are the cardiorenal effects of combining SGLT2is with GLP-1 RAs? | With Dr Darren McGuire
Category: Health
Duration: 00:14:19
Publish Date: 2021-06-29 11:17:12
Description:

While GLP-1 RAs and SGLT2is have a lot of data to support their cardio and renal protective effects, the precise mode of action for these effects remains unknown. Trials like EMPEROR-reduced, DAPA-HF and DAPA-CKD have shown that these effects, in the case of SGLT2is, are independent of diabetes status, and similar trials are ongoing in GLP-1 RAs.

So what happens if we use both agents? Could this produce an additive cardioprotective effect, or might they cancel each other out? In this episode we discuss these questions with Dr Darren McGuire, Professor of Internal Medicine at the University of Texas Southwestern Medical Center in the Division of Cardiology, whose expertise is in large scale CVOTs and drug regulation in the field of diabetes and cardiology.

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Disclosures:

Dr. Darren McGuire declares the following:

Clinical trial leadership: AstraZeneca, Boehringer Ingelheim, Eisai Esperion, GlaxoSmithKline, Janssen, Lexicon, Merck & Co. Inc, Novo Nordisk, Sanofi, CSL Behring

Consultancy: Affimune, Applied Therapeautics, AstraZeneca, Boehringer Ingelheim, Lilly, Merck & Co. Inc, Pfizer Inc, Novo Nordisk, Metavant, Sanofi

All conflicts of interest have been mitigated prior to this activity.


Funding statement:

This independent educational activity is supported by an educational grant from Eli Lilly, Merck Sharp and Dohme Corp. and Novo Nordisk A/S. The educational content has been developed by Liberum IME in conjunction with an independent steering committee; the financial supporters have had no influence on the content of this education.
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